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Published by , Monday, June 09th 2014

How the case against the MMR vaccine was fixed

In the first part of a special BMJ series, Brian Deer exposes the bogus data behind claims that launched a worldwide scare over the measles, mumps, and rubella vaccine, and reveals how the appearance of a link with autism was manufactured at Canada Goose Outlet a London medical schoolWhen I broke the news to the father of child 11, at first he did not believe me. "Wakefield told us my son cheap Canada Goose was the 13th child they saw," he said, gazing for the first time at the now infamous research paper which linked a canada goose clearance sale purported new syndrome with the measles, mumps, and rubella (MMR) vaccine.1 "There's only 12 in this."That paper was published in the Lancet on 28 February 1998."Onset of behavioural symptoms was associated by the parents with measles, mumps, and rubella vaccination in eight of canadian goose jacket the 12 children," began the paper's "findings." Adopting these claims as fact,4 its "results" section added: "In these eight children https://www.canadagooseisverige.com the average interval from exposure to first behavioural symptoms was 6.3 days (range 1 14)."Mr 11, an American engineer, looked again at the buy canada goose jacket paper: a five page case series of 11 boys and one girl, aged between 3 and 9 years. Nine children, it said, had diagnoses of "regressive" autism, canada goose deals and all but one were reported with "non specific colitis." The "new syndrome" brought these together, linking brain and bowel diseases. His son was the penultimate case.Running his finger across the paper's tables, over coffee in London, Mr 11 seemed reassured by his anonymised son's age and other details. But then he pointed at table 2 headed "neuropsychiatric diagnosis" and for a second time objected."That's not true."Child canada goose coats 11 was among the eight whose parents apparently blamed MMR. The interval between his vaccination and the first "behavioural symptom" was reported as 1 week. This symptom was said to have appeared at age 15 months. But his father, whom I had tracked down, said this was wrong."From canada goose the information you provided me on our son, who I was shocked to hear had been included in their published study," he wrote to me, after we met again in California, "the data clearly appeared to be distorted."He backed his concerns with medical records, including a Royal Free discharge summary.5 Although the family lived 5000 miles from the hospital, in Canada Goose online February 1997 the boy (then aged 5) had been flown to London and admitted for Wakefield's project, the undisclosed goal of which was to help sue the vaccine's manufacturers.6Wakefield's "syndrome"Unknown to Mr 11, Wakefield was working on a lawsuit,7 for which he sought a bowel brain "syndrome" as its centrepiece. Claiming an undisclosed 150 (180, $230) an canada goose clearance hour through a Norfolk solicitor named Richard Barr, he had been confidentially 8 put on the payroll two years before the paper was published, eventually grossing him 435643, plus expenses.9Curiously, however, Wakefield had already identified such a syndrome before the project canada goose coats on sale which would reputedly discover it. "Children with enteritis/disintegrative disorder [an expression he used for bowel inflammation and regressive autism10] form part of a new syndrome," he and Barr explained in a confidential grant application to the UK government's Legal Aid Board11 before any of the children were investigated.12 "Nonetheless the evidence is undeniably in favour of a specific vaccine induced pathology."The two men also aimed to show a sudden onset "temporal association" strong evidence in product liability. "Dr Wakefield feels that if we can show a clear time link between the vaccination and onset of symptoms," Barr told the legal board, "we should be able to dispose of the suggestion that it's canada goose black friday sale simply a chance encounter."13But child 11's case must have proved a disappointment. Records show his behavioural symptoms started too soon. "His developmental milestones were normal until 13 months of canada goose outlet age," notes the discharge summary. "In the period 13 18 months he developed slow speech patterns and repetitive hand movements. Over this period his parents remarked on his slow gradual deterioration."That put the first symptom two months earlier than reported Canada Goose sale in the Lancet, and a month before the boy received the MMR vaccination. And this was not the only anomaly to catch the father's eye. What the paper reported as a "behavioural symptom" was noted in the records as a chest infection."Please let me know if Andrew W has his doctor's license revoked," wrote Mr 11, who is convinced that many vaccines and environmental pollutants may be responsible for childhood brain disorders. "His misrepresentation of my son in his research canada goose store paper is inexcusable. His motives for this I may never know."The father need not have worried. My investigation of the MMR issue exposed the frauds behind Wakefield's research. Triggering the longest ever UK General Medical Council fitness to practise hearing, and forcing the Lancet to retract the paper, last May it led to Wakefield and Walker Smith being struck off the medical register.14 15 16Wakefield, now 54, who called no witnesses, was branded "dishonest," "unethical," and "callous."14 15 16 Walker Smith, now 74, the senior clinician in the project, was found to have presided over "high risk"17 research without clinical indication or ethical approval. The developmentally challenged children of often vulnerable parents were discovered to have been treated like the doctors' guinea pigs.18Lawsuit test caseBut Mr 11 was not the first parent with a child in the study whom I interviewed during my inquiries. That was Mrs 2: the first of the parents to approach Wakefield. She was sent to him by an anti vaccine campaign called JABS.19 Her son had regressive autism,20 longstanding problems with diarrhoea,21 and was the prime example of the purported bowel and brain syndrome still unsubstantiated 14 years later.22 This boy would appear in countless media reports, and was one of the four "best" cases in Barr's lawsuit.I travelled to the family home, 80 miles northeast of London, to hear about child 2 from his mother. That was in September 2003, when the lawsuit fell apart after counsel representing 1500 families said that, on the evidence, Barr's autism claims would fail.23 By that time, Mrs 2 had seen her son's medical records and expert reports written for her case at trial.Her concerns about MMR had been noted by her general practitioner when her son was 6 years old.24 But she told me the boy's troubles began after his vaccination, which he received at 15 months.25 "He'd scream all night, and he started head banging, which he'd never done before," she explained."When did that begin, do you think?" I asked."That began after a couple of months, a few months afterward, but it was Canada Goose Jackets still, it was concerning me enough, I remember going back...""Sorry. I don't want to be, like, massively pernickety, but was it a few months, or a couple of months?""It was more like a few months because he'd had this, kind of, you know, slide down. He wasn't right. He wasn't right. Before he started.""Not quicker than two months, but not longer than how many months? What are we talking about here?""From memory, about six months, I think."The next day, she complained to my editors. She said my methods "seemed more akin to the gutter press." But I was perplexed by her story, since there was no case in the Lancet that matched her careful account.

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